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The combination of PIO with GLP-1R agonists also demonstrated significant reductions of hepatic fat content, liver indices, as well as markers of inflammation and fibrosis (Table I)
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While each intervention is effective on its own, their co-administration could lead to enhanced outcomes by targeting complementary pathways, potentially overcoming individual limitations such as adherence challenges with exercise or bioavailability issues with some polyphenols (1517)
Yamamoto M, Bando H
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